CONTRAVE®: Frequently Asked Questions (FAQs)

Got questions about CONTRAVE? Read through our frequently asked questions and see if we address your query here. If not, get in touch with us with this form or give us a call at 888-354-5658 to find out more about CONTRAVE, Diet Doc, and medical weight loss today!


CONTRAVE is an innovative diet drug offered by Diet Doc to help with hunger pangs and cravings. It’s a prescription solution containing a combination of bupropion and naltrexone. Bupropion is an antidepressant that can also decrease appetite, while naltrexone blocks the effects of narcotics or alcohol and can also curb hunger and food cravings.


Yes, CONTRAVE is approved by the FDA to help manage weight in obese or overweight adults with weight-related medical problems. It is approved for use in conjunction with diet and exercise. It is not approved to treat conditions such as high blood pressure, diabetes, or high cholesterol.

Does Insurance cover CONTRAVE?

Consult with your insurance carrier to determine if they will cover your CONTRAVE prescription from a Diet Doc doctor. In general, Medicare does not cover this medication.


CONTRAVE is safe for use in patients for whom it has been prescribed. Make sure to tell your doctor about other prescriptions you take, including any that contain other forms of bupropion or contain narcotics. It should not be used in pregnant patients or those going through withdrawal from alcohol or drug addiction.


Take this medication as prescribed by your doctor. Don’t take it in larger or smaller doses than prescribed. Don’t crush, chew, or break the tablet. It should be swallowed whole, not more than two tablets at once.

How Long Does it Take for CONTRAVE to Work?

Most patients who respond to CONTRAVE's treatment will do so in four months. If you haven’t experienced meaningful weight loss (5% of total body weight) after four months, contact your doctor for alternate strategies to consider.

Should I Take CONTRAVE With Food?

CONTRAVE is taken in the morning and the evening, with an increasing schedule until the maintenance dose of two tablets orally twice a day. You may take CONTRAVE with food, but do not take CONTRAVE with a high-fat meal, as that could cause a seizure.

Can You Drink Alcohol While Taking CONTRAVE?

Drinking alcohol with CONTRAVE can increase your risk of seizure. If you regularly drink alcohol, discuss with your doctor before modifying your alcohol intake. Bupropion can cause seizures in patients who suddenly withdraw from drinking.

Is CONTRAVE Addictive?

As naltrexone is an anti-addiction drug, it is not likely CONTRAVE will be addictive.

Can I Stop Taking CONTRAVE Abruptly?

CONTRAVE is not known to have negative side effects from immediate discontinuance. If you need to stop using it abruptly due to needing to take a narcotic or because it’s not working for you, there shouldn’t be any adverse side effects.

CONTRAVE can help when diet and exercise aren’t enough. You can lose 2-3 times more weight than with a placebo. Consult with a Diet Doc medical professional today to develop a weight loss plan and see if CONTRAVE is right for you.

Please see Important Safety Information and Full Prescribing Information, including boxed warning at

CONTRAVE® is a registered trademark of Orexigen Therapeutics, Inc. registered with the U.S. Patent and Trademark Office.


Join the 55,000 Diet Doc patients who met their weight loss goals by signing up for your CONTRAVE consultation today.