What Are the Active Ingredients in CONTRAVE®?

It can be a scary thing to decide to accelerate your weight loss with CONTRAVE. There’s no need to worry when you choose to lose weight with Diet Doc. We provide all the tools and knowledge necessary to make the right decisions that lead to the right results.

Active Ingredients in CONTRAVE

Patients just starting their weight loss journey often wonder, “What is in CONTRAVE?” They’re concerned about drug interactions with CONTRAVE, or how much bupropion (Wellbutrin) or naltrexone is in it. Alleviate your concerns with our CONTRAVE active ingredients guide.


Its chemical name is naltrexone hydrochloride. This ingredient is an opioid antagonist, which means it occupies receptors in your brain and prevents them from reacting with agonists. In the case of naltrexone, the brain stops reacting to opioids.

Its typical use is as an antidepressant, but it has a miraculous effect when combined with CONTRAVE's other active ingredient, bupropion. Physicians and researchers have yet to fully understand what processes cause the two medications to improve weight loss when used in combination, but the results speak for themselves.


Its chemical name is bupropion hydrochloride. It works differently than naltrexone, and its typical use is as an antidepressant. However, its primary function shifts in the presence of naltrexone.

The two active ingredients in CONTRAVE, when combined, make weight loss and weight maintenance easier. They don’t work on their own, though. Qualified doctors, like those at Diet Doc, must include a healthy diet and exercise plan along with a prescription for the naltrexone and bupropion combination, CONTRAVE.

Contraindications for CONTRAVE

Diet Doc’s medical experts will help you determine whether CONTRAVE is right for you. If you are affected by any of the following, CONTRAVE may be dangerous to you:

  • Hypertension, especially uncontrolled
  • Seizure disorder
  • History of seizures
  • Use of bupropion-containing products (such as Wellbutrin)
  • Opiate withdrawal
  • Alcohol or drug withdrawal
  • Bulimia
  • Anorexia nervosa
  • Use of an MAOI (monoamine oxidase inhibitor)
  • Allergy to what is in Contrave
  • Pregnancy or potential pregnancy

CONTRAVE Drug Interactions

CONTRAVE has known drug interactions with the following medications:

  • Monoamine Oxidase Inhibitors (MAOI) – Use of CONTRAVE concurrent with an MAOI can cause severe hypertensive reactions. Allow at least 14 days between the discontinuation of an MAOI and the beginning of use of CONTRAVE.
  • Opioid Analgesics – Patients taking CONTRAVE have a compromised ability to receive opioids. Accordingly, opioid-based analgesics are likely to have low or no effect.

Other drug interactions with CONTRAVE include:

  • CYP2D6, such as metoprolol
  • Digoxin
  • CYP2B6 inhibitors
  • CYP2B6 inducers
  • Drugs that lower seizure threshold, such as antipsychotics
  • Dopaminergic drugs
  • Alcohol


CONTRAVE is a product of Orexigen Therapeutics, Inc. It is highly tested and has produced groundbreaking results when used according to directions provided by a qualified medical professional.

Get started with Contrave today and say hello to a newer, healthier, livelier you sooner than you ever thought before!

Please see Important Safety Information and Full Prescribing Information, including boxed warning at

CONTRAVE® is a registered trademark of Orexigen Therapeutics, Inc. registered with the U.S. Patent and Trademark Office.


Join the 55,000 Diet Doc patients who met their weight loss goals by signing up for your CONTRAVE consultation today.