Low Dose Naltrexone (LDN)

Emotional eating and uncontrollable snacking can lead to huge weight gains and prevent you from reaching your weight loss goals. If you find that you’re prone to emotional eating or unable to resist snacking, consider using low dose naltrexone for weight loss. In conjunction with support from one of our professional weight loss coaches, low dose naltrexone will help keep you on track as you reach your target weight.

What Is Naltrexone?

Naltrexone was first synthesized by Drs. Jack Fischman and Mozez Lewenstein at the Memorial Sloan Kettering Institute for Cancer Research in 1961. Naltrexone is an opioid receptor antagonist, originally used to treat opiate and alcohol addiction. When taken in smaller doses, low dose naltrexone has been shown to lessen the effects of a variety of diseases and help modulate and reduce appetite. Patients use LDN today to reduce binge eating episodes, normalize appetite, and lose stubborn fat quickly.

How Does Low Dose Naltrexone Work?

The FDA approved Contrave, a combination weight loss medication containing naltrexone HCL and bupropion HCL, to treat overweight and obese patients. Bupropion increases dopamine levels in your brain, while LDN works to suppress your appetite. Combination weight loss medications like these may improve your mood and suppress your sugar and carb cravings to stop overeating once and for all.

Take low dose naltrexone to:

  • Regulate appetite: Naltrexone helps normalize your metabolism, matching your appetite to resting energy expenditures.
  • Reduce insulin resistance: Naltrexone modulates cellular resistance to insulin, which may lead to weight loss.
  • Improve sleep: Lack of sleep has negative effects on your body’s hormonal system, which can lead to weight gain. Naltrexone combats this unhealthy cycle.
  • Improve mood: Combination LDN weight loss medications trigger an increase in serotonin and dopamine production, which decreases anxiety and stress and reduces emotional eating.

Naltrexone is not an effective solution for every patient, but it is generally easy to tolerate. Patients who don’t see any benefits from LDN typically don’t experience negative side effects either. Some patients for whom the drug is effective have reported feelings of nausea, insomnia, loss of appetite, and fatigue, but this is rare. Make sure you consult your weight loss coach or doctor before taking low dose naltrexone to learn about possible side effects and drug interactions.

Does Naltrexone Work for Weight Loss?

While results vary from person to person, low dose naltrexone makes losing weight easier for those who are prone to overeating, especially when taken under the direction of a certified weight loss coach. Diet Doc is proud to have helped many patients successfully use low dose naltrexone as they work toward their weight loss goals. When used in combination with a healthy diet and moderate exercise routine, LDN will yield great results.

How to Get Naltrexone

LDN is administered as part of Diet Doc’s medically supervised weight loss plans. It can be even more effective when combined with other Diet Doc prescription medications, such as OxytocinMetWell, or Sermorelin.

Call us today or send us a message to learn more about LDN therapy and our medical weight loss programs. You’ll learn about our comprehensive weight loss solutions and get the opportunity to speak with a weight loss doctor who can help you identify your toughest obstacles and the best plan for achieving your goals. We’ll even ship your medication the same day so you can get started right away.

Frequently Asked Questions

How to take Low Dose Naltrexone

Your doctor will prescribe a low dose of naltrexone to take each day (dosages depend on the amount of weight the individual wants to lose, typically ranging from 1.5mg-4.5mg for off-label uses and 50-150mg when administered in a clinical setting). Medications come in standard pill form or injections.

When to take Low Dose Naltrexone

At home, LDN is usually taken once a day with or without food. You shouldn’t take more or less of the drug than is recommended by your doctor.

What to avoid when taking Low Dose Naltrexone

Tell your doctor about all prescriptions you’re taking, including recreational, herbal, nutritional, and dietary supplements. Be sure to tell your doctors if you’re taking opioid medications, disulfiram, thioridazine, or medications for diarrhea, cough, or pain. You shouldn’t take naltrexone while consuming alcohol or cold medicines that contain alcohol.

How long does it take for Low Dose Naltrexone to work?

Moderate to long-term usage yields better results than short-term usage. Patients can expect to see results within several months of taking Low Dose Naltrexone.

Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act requires this notice.


Join the 150,000+ Diet Doc patients who met their weight loss goals by requesting a consultation today.

Learn More on the Diet Doc Blog

woman pinching stomach fat

The Difference Between Subcutaneous and Visceral Fat

Losing weight comes with obvious challenges, but an underdiscussed roadblock is a lack of awareness of the biology behind your...
Runners racing a local 5K around a lake on a dirt path on a early summer evening.

5 Ways to Prepare for a 5K

What is your definition of being in shape? For many people, being able to complete a 5K run is an...
6 Tips for Reducing Your Sugar Intake

6 Tips for Reducing Your Sugar Intake

Americans are consuming too much sugar. The Department of Health and Human Services estimates that the average American has about...