TZP is a GLP-1 drug that is taken once-weekly as an injectable to regulate blood sugars, reduce hemaglobin A1C levels and assist with weight loss.
Medication for Weight Loss
Tirezepatide is a glucagon-like peptide 1 agonist that induces weight loss by controlling appetite. Losing excess weight can provide many health benefits by improving cardiovascular health, metabolic health, and restoring hormones, such as testosterone, to their baseline levels.
Mounjaro™ works similarly to the other drugs in the GLP-1 family, but it contains an extra molecule that may give it a slight edge.
The medication has a dual-action design, mimicking the action of not one but two unique incretin hormones involved in blood sugar control: on-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This unique dual action makes it the first-in-class medicine that acts on both of these receptors.
GIP is a hormone that may complement the effects of GLP-1 receptor agonists. In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids.
Incretin hormones are released whenever food is consumed. Among other things, they help promote a feeling of fullness by delaying gastric emptying and activating the satiety centers of the brain. They also boost insulin production in the pancreas, and suppress glucagon production, both of which help normalize blood sugar. All of this happens in a glucose-dependent manner, which means incretin hormones—or their imitators, i.e. GLP-1 and GIP receptor agonists—are unlikely to cause severe hypoglycemia.
What about your natural incretin hormones? Studies have found that people with overweight or obesity may have a reduction in incretin effects, particularly if they have had frequent weight fluctuations due to yo-yo dieting. GLP-1 medication narrows the gap, making it easier to reach your goals and lower your metabolic set point.
Losing excess weight can provide many health benefits by improving cardiovascular health, metabolic health, and restoring hormones, such as testosterone, to their baseline levels.
Obesity, insulin resistance, dyslipidemia, and cardiovascular disease have all been linked to low B12 levels. B12 is involved in regulating DNA coding for proteins (epigenetics) and many metabolic processes in the cell. There is mounting evidence that B12-DNA interactions regulate lipid metabolism and play a role in fat deposition